相关实验视频

Updated: Sep 11, 2025

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

果糖增强肠道发育和屏障功能,同时在 brojlers 中驱动肝脏脂肪生成和炎症

Liping Gan¹, Ningyu Geng¹, Qiqi Yang¹

¹School of Bioengineering, Henan University of Technology, Zhengzhou 450001, Henan, China.

Poultry science

|August 17, 2025

概括

牛肉饮食中的果糖补充改善了肠道健康和肠道发育,但没有影响生长性能. 然而,它降低了脂肪的消化能力,增加了肝脏脂肪的合成和炎症.

科学领域:

动物科学动物科学
营养科学营养科学
胃肠病学胃肠病学

背景情况:

果糖是一种常见的碳水化合物,可能对动物健康产生影响.
了解果糖对肉肠道健康和新陈代谢的影响对于优化家禽生产至关重要.

研究的目的:

研究饮食中的果糖对肉肠道健康,营养代谢和生产性能的影响.
阐明果糖对肉生理学的影响背后的机制,包括肠道形态,微生物群和肝功能.

主要方法:

使用 brojler肠道有机体的体外研究.
在体内试验中,96只肉被食商业饮食,在饮用水中补充1%的果糖42天.
分析生长性能,尸体特征,营养消化能力,基因表达 (ACC1,Srebf1,CPT1),血清代谢物,肝炎标志物 (IL-1β,5-HETE),肠道形态和肠道微生物群组成.

主要成果:

果糖在体外增加了肠道器官的尺寸.
在体内,果糖没有影响体重,料摄入量或料转化率 (FCR),但增加了成衣百分比.
果糖降低了明显的原油脂肪消化能力,增强了肝脂发生 (上调ACC1,Srebf1;下调CPT1) 和诱导肝炎 (增加IL-1β,5-HETE).
肠道形态有所改善,状体高度增加至密室深度比和较长的十二指肠/阴茎,以及上调的紧结基因表达.
果糖改变了肠道微生物群的组成,降低了Firmicutes与Bacteroidota的比率,并影响了血清脂质代谢途径.

结论:

在 brojiler饮用水中补充1%的果糖可以促进肠道发育,并改变微生物组成,而不会影响生长性能.
果糖对食脂肪的消化能力产生负面影响,并促进肝脏脂肪生成和炎症.
需要进一步的研究,以平衡肠道健康的益处与可能对肝功能和肉营养利用的潜在不良影响.

关键词:

肉牛肉是什么意思脂肪新陈代谢脂肪新陈代谢果糖是葡萄糖中的一种果糖.肠道生长肠道生长血清代谢物的血清代谢物

更多相关视频

Isolation of Preadipocytes from Broiler Chick Embryos

Isolation of Preadipocytes from Broiler Chick Embryos

Published on: August 4, 2022

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

相关概念视频

Overview of Carbohydrate Metabolism

Overview of Carbohydrate Metabolism

Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...

Glucose Absorption Into the Small Intestine

Glucose Absorption Into the Small Intestine

Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...