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Updated: Sep 11, 2025

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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核孔综合体功能障碍驱动ALS中的TDP-43病理.

O Ramírez-Núñez1, S Rico-Ríos1, P Torres1

  • 1Metabolic Pathophysiology Research Group, Dept of Experimental Medicine, University of Lleida-IRBLleida, Avda Rovira Roure, 80 E25196, Lleida, Spain.

Redox biology
|August 17, 2025
PubMed
概括

核毛孔复合体 (NPC) 功能障碍和TDP-43病理是肌缩侧面硬化症 (ALS) 的关键. 氧化应激会损害NPCs,推动ALS的进展,并突出了核细胞质运输作为治疗目标.

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