延丹Xinnaotong软囊通过调节CREB/BDNF介导的突触可塑性和CREB/VEGFA介导的血管新生来改善缺血性中风后的恢复
Cuicui Cheng1, Huijuan Liu1, Guoqiang Guan1
1National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China.
概括
延丹Xinnaotong软囊 (YD) 通过CREB途径增强突触可塑性和血管生成,有助于缺血性中风的恢复. 这种传统中医药在长期脑缺血损伤方面显示出治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 缺血性中风是长期残疾和认知障碍的主要原因.
- 延丹Xinnaotong软囊 (YD) 用于心脑血管疾病,但其在中风恢复中的作用尚不清楚.
研究的目的:
- 研究YD对缺血性中风恢复的保护作用.
- 阐明YD在中风后的作用的基本机制.
主要方法:
- 使用的中脑动脉阻塞/再输液 (MCAO/R) 和氧气-葡萄糖剥夺/再输液 (OGD/R) 模型.
- 评估了大脑缩,组织病理学,突触超结构和行为结果.
- 采用RNA-seq,网络药理学,分子对接和体外/体内验证.
主要成果:
- YD治疗显著减少了大脑缩,神经缺陷和病理损伤.
- 确定了涉及CREB,BDNF和VEGFA的CREB信号通路作为一个关键机制.
- YD上调了突触可塑性和血管生成标记物,Salvianolic acid B和Kaempferol-3-O-rutinoside被确定为活性成分.
结论:
- YD通过增强CREB/BDNF介导的突触可塑性来促进经缺血性中风的恢复.
- 此外,YD还促进了CREB/VEGFA介导的血管生成,这表明脑缺血的治疗潜力.
- 这项研究强调了YD在缺血性脑损伤的长期康复中的有效性.
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