作为延长献血间隔 (FORTE) 的替代品或补充剂的费里丁导导铁补充剂:一项双盲,随机,受控试验
Jan H M Karregat1, Amber Meulenbeld2, Franke A Quee3
1Donor Health, Department of Research, Sanquin Blood Supply Foundation, Amsterdam, Netherlands; Department of Public and Occupational Health, Amsterdam UMC, Amsterdam, Netherlands; Amsterdam Public Health (APH) Research Institute, Amsterdam UMC, Amsterdam, Netherlands; Department of Medical Biosciences, Radboudumc, Nijmegen, Netherlands.
The Lancet. Haematology
|August 17, 2025
概括
口服铁补充剂有效地对抗铁缺乏和低血红蛋白在定期献血者低费里. 每天60毫克的铁是特别有效的,为延长捐赠间隔提供了替代品.
科学领域:
- 血液学 血液学 血液学
- 营养科学 营养科学
- 临床试验 临床试验
背景情况:
- 定期献血与铁缺乏和贫血的风险增加有关.
- 口服铁补充剂可以缩短捐赠后的铁恢复时间.
- 这项研究评估了在献血者中铁补充方案与安慰剂的对比.
研究的目的:
- 评估不同铁补充方案对费里丁和血红蛋白水平的影响.
- 评估胃肠道副作用和缺铁症状.
- 将捐赠者回归率与安慰剂补充剂进行比较.
主要方法:
- 在7个献血中心进行双盲,随机,安慰剂对照试验.
- 830名费里含量低 (≤30μg/L) 的捐赠者每天或每隔一天接受铁二糖 (0,30或60毫克元素铁),持续56天.
- 主要结局:缺铁 (<15μg/L),低费里丁 (15-30μg/L) 和低血红蛋白在56天.
主要成果:
- 所有铁补充剂组在56天内,与安慰剂相比,铁缺乏的几率显著降低.
- 每天60毫克的铁补充剂在缓解缺铁,低费里丁和低血红蛋白方面特别有效.
- 副作用是最小的,其中一个事件可能与干预相关 (偏头痛增加).
结论:
- 补充铁,特别是每天60毫克,有效地解决铁缺乏在定期献血者低费里.
- 口服铁对于这些捐赠者来说是延长捐赠间隔的可行替代品或补充.
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