关于大麻对人类认知的急性影响的性别差异:系统性审查
Justin Matheson1, Danial Behzad1, Christina Zakala2
1Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada.
Frontiers in neuroendocrinology
|August 17, 2025
概括
这次审查发现,大麻或三角-9-四大麻 (THC) 的急性认知影响中性别差异的证据有限. 需要更多的研究来了解性如何影响大麻.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 心理学 心理学 心理学
背景情况:
- 急性大麻暴露会损害认知功能,增加事故风险.
- 以前的研究表明,大麻反应中存在性别差异,但这还没有系统地审查急性认知影响.
研究的目的:
- 检查大麻和delta-9-tetrahydrocannabinol (THC) 对人类急性认知影响的性别差异.
- 为了确定这些性别差异是否因认知领域,施用途径或剂量范式而有所不同.
主要方法:
- 在主要的科学数据库 (Embase,MEDLINE,APA PsycInfo,Cochrane Library,Web of Science) 中进行了系统的文献搜索.
- 研究按照PRISMA指南进行了选,其中29项研究符合纳入标准.
- 关于认知结果,性别差异和研究参数的数据被提取和分析.
主要成果:
- 仅有20.7%的纳入文章 (共29篇文章中的6篇) 在急性大麻/THC认知影响方面报告了统计学上显著的性别差异.
- 其中,大多数发现女性的效果更大,一些研究报告男性的效果或不同的效果.
- 在认知领域,施用途径或剂量范式中没有观察到性别差异的明确模式.
结论:
- 目前有有限的证据表明,性别显著影响大麻的急性认知效应.
- 现有研究中的方法异质性阻止了坚定的结论.
- 未来的研究应该纳入与性别相关的因素,包括对大麻素相互作用的荷尔蒙影响.
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