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组织学反应与改善食道张延能力和儿科eosinophilic食道炎的症状负担有关

Kanak Kennedy¹, Cassandra Burger², Zhaoxing Pan³

¹Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA.

Gastroenterology

|August 17, 2025

概括

组织学缓解改善了儿科异性食道炎 (EoE) 中食道张延能力. 基线食道延展性预测了患有EoE的儿童的疾病严重程度和纤维肌性并发症.

科学领域:

胃肠病学胃肠病学
儿科过敏和免疫学
食道疾病食道疾病

背景情况:

慢性乙性食道炎 (EoE) 可以导致食道组织的逐渐重塑和纤维化.
儿童EoE的纵向数据有限,特别是关于组织学控制的影响.
儿科EOE中食道延伸性,组织学和纤维系结局之间的关系尚不清楚.

研究的目的:

评估患有EoE的儿童食道张张能力的纵向变化.
评估食道张张力,组织学疾病控制和纤维肌性并发症之间的关联.
为了确定基线食道延伸性是否可以预测疾病的严重程度和进展.

主要方法:

在两个儿科三级保健中心进行的前性纵向研究.
包括3-18岁的儿科受试者与EoE.
在连续内镜检查期间使用阻抗平面度测量食道张张能力.
在每次访问时收集症状,内镜和组织学数据.

主要成果:

对治疗的组织学反应随着时间的推移显著改善了食道张张能力 (1.41比0.16-0.53毫米/年,p=0.003).
较低的食道张力独立地与失消的可能性增加有关 (OR 0.85,CI 0.75-0.96,p = 0.008).
患有纤维质症的患者在诊断时年龄较大,疾病持续时间较长,基线延展能力较低 (p < 0.05).
基线延展性预测了未来狭窄扩张的需要 (AUC 0.757,p = 0.0003).

结论:

儿科EoE的组织学缓解与改善的食道延展性有关.
基线食道张张力作为组织重塑的定量标志物.
食道张张力可能有助于预测患有EoE的儿童的疾病严重程度和纤维化的进展.

关键词:

埃索诺菲尔性食道炎是什么意思消化道延伸性消化道延伸性纤维质症 (Fibrostenosis) 是一种纤维质症.组织学缓解组织学缓解组织改造组织改造

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