绿色合成的纳米颗粒对实验性循环多病的治疗潜力
Nehal N Hezema1, Marwa M Eltarahony2, Heba Afifi3
1Department of Medical Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Scientific reports
|August 17, 2025
概括
绿色合成的纳米粒子 (SeNPs) 通过显著减少寄生虫卵囊并改善肠道健康,有效地治疗小鼠的环. 这些生物的SeNP显示承诺作为一个安全和强大的抗氧化剂纳米疗法对循环毛病.
科学领域:
- 纳米医学是一种纳米医学.
- 寄生虫学的寄生虫学
- 绿色合成是一种绿色合成.
背景情况:
- 赛克洛斯波拉 (Cyclospora cayetanensis) 会导致衰弱性腹,特别是在免疫受损的个体中.
- 目前用于循环毛病的治疗方法存在局限性,包括严重的副作用和高复发率.
研究的目的:
- 为了评估绿色合成的纳米颗粒 (SeNPs) 对免疫抑制小鼠的治疗疗效,对Cyclospora cayetanensis感染.
主要方法:
- 纳米粒子 (SeNPs) 使用Alcaligenes faecalis.生物合成.
- 免疫抑制小鼠感染了C. cayetanensis,并用SeNPs (10 mg/kg) 口服治疗.
- 通过寄生虫学,超结构学,遗传病学和生物化学分析来评估治疗疗效.
主要成果:
- 在感染后的第30天,SeNPs治疗导致便卵囊负担显著减少97.96%.
- 超结构分析显示,SeNPs治疗后寄生虫卵囊变形.
- 组织病理学和生物化学研究表明肠道结构得到改善,炎症减少,抗氧化活性增强 (增加GSH,减少MDA).
结论:
- 生物SeNPs表现出显著的抗环菌活性和强大的抗氧化特性.
- SeNPs代表了一种安全而有前途的纳米治疗方法,用于治疗实验性环多症.
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