增加的三级淋巴体结构与肺结核吸烟者的过度肺组织损伤有关
Yue Zhang1, Liang Li2, Zi Kang Sheng1
1Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.
Biomedical and environmental sciences : BES
|August 17, 2025
概括
在结核病 (TB) 患者中,吸烟会增加三级淋巴体结构 (TLS),恶化肺损伤. 这表明吸烟促进了TLS的形成,加剧了结核病中的肺损伤.
科学领域:
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 吸烟是已知的风险因素,可恶化肺结核病 (TB) 的进展.
- 三级淋巴体结构 (TLS) 在慢性肺病中越来越被认可,但它们在与吸烟有关的结核病恶化中的作用尚不清楚.
研究的目的:
- 研究结核病吸烟者肺部TLS的特征.
- 探索TLS在结核病患者吸烟相关肺损伤中的潜在作用.
主要方法:
- 分析了36名男性肺结核患者 (18名吸烟者,18名非吸烟者) 的肺组织.
- 病理学,免疫组织学和胸部CT成像被用于评估TLS数量,免疫细胞,化学因子和病变严重程度.
- 分析了TLS数量与结核病病变严重程度之间的相关性.
主要成果:
- 与非吸烟者相比,患有结核病的吸烟者具有显著更高的TLS量 (P < 0.001).
- 胸部CT上的TLS数量与结核病变严重程度的相关性,无论是在肺膜膜 (r = 0.5767) 和周支气管区域 (r = 0.7373) (P < 0.001).
- 在结核病吸烟者中观察到B细胞,T细胞和CXCL13表达的增加 (P < 0.001).
结论:
- 吸烟者结核病患者表现出增加的肺TLS.
- 增加的TLS与加剧的肺病变有关,这表明吸烟促进了TLS的形成,并加剧了结核病的肺损伤.
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