怀孕和胎儿结局在患有型肝炎病毒病的母亲的回顾性研究
Wen Deng1, Zi Yu Zhang1, Xin Xin Li1
1Department of Hepatology Division 2, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China;HBV Infection, Clinical Cure and Immunology Joint Laboratory for Clinical Medicine, Capital Medical University, Beijing 100015, China.
Biomedical and environmental sciences : BES
|August 17, 2025
概括
慢性型肝炎病毒 (HCV) 感染会影响孕妇的肝功能,但不会增加怀孕或分娩风险. 然而,HCVRNA阳性是新生儿黄的重要危险因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 病毒学 病毒学
背景情况:
- 慢性型肝炎病毒 (HCV) 感染会影响肝功能.
- 肝炎病毒对怀孕结果的影响需要进一步调查.
研究的目的:
- 为了评估慢性HCV感染在怀孕期间对母亲肝功能的影响.
- 评估HCV感染妇女的怀孕和分娩并发症.
- 确定HCV对新生儿发育和并发症的影响.
主要方法:
- 一项比较研究包括157名HCVRNA阳性 (C组),121名HCV抗体阳性/RNA阴性 (B组) 和142名控制 (A组) 孕妇.
- 分析了生物化学指数,妊娠并发症,分娩细节和新生儿结果.
主要成果:
- 与对照组相比,HCV RNA阳性女性在整个怀孕期间表现出明显更高的氨酸转移酶 (ALT) 水平 (P <0.05).
- 不同组之间没有观察到新生儿形率的显著差异 (P > 0.05).
- 新生儿黄发病率在HCVRNA阳性女性 (75.16%) 与对照组 (42.25%-57.02%) (P < 0.001) 中显著较高.
结论:
- 慢性HCV感染会在怀孕期间损害母亲的肝功能.
- 怀孕期间的HCVRNA阳性是新生儿黄的独立风险因素 (OR = 2.111,P = 0.006).
- 感染HCV似乎不会增加怀孕或分娩并发症的风险.
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