在北海道研究中,妊娠年龄相对小和5岁的神经发育障碍之间的关联在北海道研究中
Satoshi Suyama1, Mariko Itoh2, Naomi Tamura2
1Funded Research Division of Child and Adolescent Psychiatry, Hokkaido University Hospital, Sapporo, Japan.
概括
对于妊娠年龄 (SGA) 较小的婴儿,包括按期出生的婴儿,患神经发育障碍的风险更高. 这项研究发现,SGA状态与总困难得分有显著的关联,这表明潜在的发展挑战.
科学领域:
- 儿科健康 儿科健康
- 发育神经科学的发展神经科学.
- 公共卫生 公共卫生
背景情况:
- 低出生体重是已知的发育迟缓和儿童残疾的风险因素.
- 对于妊娠年龄来说小 (SGA) 是低出生体重的关键指标,与神经发育风险增加有关.
- SGA对满期新生儿的具体影响 (满期-SGA) 需要进一步研究.
研究的目的:
- 评估SGA与儿童神经发育障碍之间的关联.
- 专门研究术语SGA对神经发育结果的影响.
- 确定导致SGA婴儿神经发育挑战的风险因素.
主要方法:
- 潜在的出生队列研究 (北海道环境和儿童健康研究).
- 包括4851名儿童,在5岁时使用优势和困难问卷 (SDQ) 进行评估.
- 使用日本儿科学会出生体重数据库评估SGA和术语SGA状态.
主要成果:
- 在多变量分析中,在SGA/term-SGA状态和总难度得分 (TDS) 之间发现了显著的关联.
- 长期SGA状态显示TDS的赔率比为1.72 (95% CI:1.07-2.76).
- SGA状态显示TDS的赔率比为1.75 (95% CI:1.10-2.78).
- 在SGA/term-SGA状态和过度活跃/不注意之间没有观察到显著的关联.
结论:
- 对于妊娠年龄来说小 (SGA) 状态,即使在新生儿中,也可能增加神经发育障碍的风险.
- 这些发现强调了监测SGA婴儿潜在的发育挑战的重要性.
- 需要进一步的研究来了解将SGA与神经发育结果联系在一起的机制.
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