胸膜Rosai-Dorfman病:一种罕见的呈现,具有不寻常的组织病理特征
Ahmed I Younes1, Tiffany Javadi1, Megan Dibbern1
1Department of Pathology, Emory University Hospital, Atlanta, GA, USA.
International journal of surgical pathology
|August 18, 2025
概括
罗莎-多尔夫曼病 (RDD) 是一种罕见的囊细胞性疾病,在38岁的女性中异常呈现为前腹中质. 这种情况突出显示了胸膜RDD与颗粒状炎症和特定的免疫组织化学标志物.
科学领域:
- 囊细胞性疾病 囊细胞性疾病
- 新生病理学新生病理学
- 免疫组织化学 免疫组织化学
背景情况:
- 罗莎-多夫曼病 (RDD) 是一种罕见的囊细胞性疾病,具有多种临床和病理表现.
- 胸膜干扰是不常见的,使RDD成为诊断挑战.
研究的目的:
- 报告一个异常的胸膜Rosai-Dorfman疾病病例.
- 描述这种罕见呈现的组织病理学和免疫组织化学发现.
主要方法:
- 计算机断层扫描 (CT) 用于初始成像.
- 胸膜组织的组织病理学检查.
- 针对特定标记物 (S-100,CD68,OCT2,环素D1,CD1a,CD20,CD5,CD3) 的免疫组织化学染色.
主要成果:
- 在CT上识别的前侧中骨软组织质量.
- 胸膜RDD与结核和非结核颗粒状炎症.
- 囊细胞对S-100,CD68,OCT2呈阳性;焦点环素D1;对CD1a呈阴性.
- 发现了反应性B和T淋巴细胞.
结论:
- 胸膜RDD可以呈现为前端中质.
- 典型的免疫组织化学特征有助于诊断.
- 成功的手术管理,在3个月内没有复发.
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