不灵活的轨道前皮层 功能连接 从休息到急性压力 在酒精使用障碍中的功能连接
Dylan E Kirsch1, Tiffany C Ho1, Kate M Wassum1
1Department of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Addiction biology
|August 18, 2025
概括
患有酒精使用障碍 (AUD) 的人在压力下表现出不灵活的大脑连接. 它们的轨道前皮层与边缘连接在休息时保持升高,阻碍了与对照组相比适应应激反应.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 适应性应对压力往往在患有酒精使用障碍 (AUD) 的人群中受损.
- 这一过程依赖于神经电路,涉及腹中前额叶皮层 (vmPFC),轨道前额叶皮层 (OFC),杏仁体,海马体和核.
- 酒精的神经毒性作用会破坏这些系统对急性压力的灵活适应.
研究的目的:
- 研究与AUD与匹配的对照对象之间的vmPFC-limbic/striatal和OFC-limbic/striatal功能连接从休息到急性压力的状态依赖的变化.
- 检查这些连接变化和应对策略之间的关联.
主要方法:
- 在休息状态下进行fMRI,随后在24名AUD成人和23名匹配对照中进行蒙特利尔成像应激任务 (MIST).
- 在休息和压力条件下评估vmPFC-limbic/striatal和OFC-limbic/striatal区域之间的功能连接.
- 使用反复测量ANCOVA和与COPE库存的相关性,分析依赖状态的连接变化中的组差异.
主要成果:
- 对照组显示右OFC-右桃体和右OFC-右海马连接性从休息到MIST增加;这种转变不在AUD组 (pFDR <0.05).
- 与对照组相比,AUD组在这些区域之间表现出较高的静止状态连接 (p < 0.05).
- 在对照组中,从休息到MIST的右OFC-海马连接性增加与更适应性应对策略相关 (p <0.05).
结论:
- 患有AUD的个体在急性压力下显示不灵活的OFC-杏仁体和OFC-海马体功能连接.
- 在AUD中,与压力相关的连接灵活性降低似乎是由休息状态功能连接性升高所驱动的.
- 这种静止状态模式可能代表一个全静止状态,限制了AUD.灵活应激反应的能力.
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