超越CBC:新型标记可以预测慢性鼻炎与鼻多重症的复发吗?
Hasan Canakci1, Hasmet Yazici2, Salih Yayman1
1Department of Otolaryngology, University Medical Center Balikesir, Balikesir, Turkey.
概括
生物标志物如乙氨基基单细胞比率 (EMR),全身免疫炎症指数 (SII) 和全身炎症反应指数 (SIRI) 可以预测慢性鼻炎与鼻多重症复发. 喘也是复发的独立预测因素.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 炎症研究 炎症研究
背景情况:
- 患有鼻多重症的慢性鼻鼻炎 (CRSwNP) 通常在术后复发.
- 需要预测CRSwNP复发的生物标志物来指导治疗和管理.
- 炎症标志物和患者特异性因素可能会影响复发风险.
研究的目的:
- 评估各种炎症标志物和临床因素在预测CRSwNP复发中的预后价值.
- 确定可靠的生物标志物,以识别患有术后复发风险较高的患者.
- 为了比较复发性和非复发性CRSwNP病例之间的炎症概况.
主要方法:
- 根据复发状态分类的CRSwNP患者的回顾性分析 (非复发与3年内复发).
- 包括一个健康的对照组进行比较分析.
- 测量和比较埃索诺菲尔数量,埃索诺菲尔-单细胞比率 (EMR),总IgE,SII,SIRI,NLR,PLR,喘存在,以及ASA敏感度.
主要成果:
- 与非复发病例相比,复发的CRSwNP病例显示总IgE和PLR显著更高.
- 与对照组相比,在复发组中观察到高氨基酸,EMR,SII和SIRI水平.
- 喘通过多变量逻辑回归被确定为术后复发的独立预测因子.
结论:
- EMR,SII和SIRI显示出作为预测CRSwNP复发的有价值生物标志物的潜力.
- 在复发病例中,这些炎症指数的升高水平强调了它们的预后意义.
- 喘的存在是与CRSwNP复发相关的关键独立因素.
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