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Updated: Jul 14, 2026

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Published on: December 7, 2014

对CHK1抑制剂的专利审查 (2019年至今)

Tao Liu¹, Mingbo Su², Yuxuan Wang³

¹Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Expert opinion on therapeutic patents

|August 18, 2025

概括

检查点激酶1 (CHK1) 抑制剂对于癌症中DNA损伤反应至关重要. 虽然许多都在临床试验中,但没有一个得到批准,这突显了在癌症治疗中需要新的选择性CHK1抑制剂的需要.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
药物发现药物发现药物发现

背景情况:

检查点酶1 (CHK1) 对DNA损伤反应 (DDR) 至关重要,它调节细胞周期检查点,DNA修复和亡.
作为癌症治疗药物,CHK1抑制剂正在被研究,有超过15个临床试验,但没有一个获得市场批准.

研究的目的:

对瘤学中CHK1抑制剂进行全面的专利审查.
分析CHK1抑制剂的组合产品和结构见解.
评估目前CHK1抑制剂开发的现状和未来发展方向.

主要方法:

从2019年1月到2024年12月的专利文献审查.
在Scopus,Espacenet,Web of Science,WIPO,谷歌专利,Cortellis和USPTO数据库中进行的搜索.

主要成果:

在不同发展阶段确定了众多CHK1抑制剂.
强调了新型骨和组合疗法的重要性.
强调了在合理药物设计和生物标志物识别方面正在进行的研究.

结论:

开发具有新型结构的强效,选择性CHK1抑制剂对于癌症治疗至关重要.
组合疗法和以生物标志物为指导的策略具有显著的前景.
为了有效的癌症治疗,CHK1抑制剂研究的进一步进展至关重要.

关键词:

一个瑞士克朗.这是一种CHK1抑制剂.在DDR中,DDR是指DDR.癌症治疗疗法癌症治疗组合组合组合的组合组合.patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent patent 预测性的生物标志物

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