开发和完善怀孕算法CErtaInty工具 (ACE-IT) 以验证怀孕结果
Sonal Singh1, Hsiao-Ching Huang2, Susan E Andrade3
1Division of Health Systems Science, Department of Family Medicine and Community Health, UMass Chan Medical School, Worcester, Massachusetts, USA.
Clinical pharmacology and therapeutics
|August 18, 2025
概括
怀孕算法CErtaInty工具 (ACE-IT) 有效地评估了怀孕结果的真实数据算法. 它被认为是可接受和适当的,用于评估算法适合决策的目的.
科学领域:
- 药学流行病学 药学流行病学
- 医疗信息学 医疗信息学
- 生物统计学 生物统计学
背景情况:
- 现实世界数据 (RWD) 对于通过算法验证研究生成现实世界证据 (RWE) 至关重要.
- 算法CErtaInty工具 (ACE-IT) 最初是为了评估基于RWD的算法对特定健康结果的适应性而开发的.
- 现有的工具需要定制,以评估专门针对怀孕和分娩结果的算法.
研究的目的:
- 改进,开发和定制ACE-IT以评估与怀孕和分娩结果相关的算法的适应性.
- 评估怀孕ACE-IT的可行性,可接受性,适当性和内容有效性.
- 确定怀孕/分娩结果的验证算法是否适合特定决策环境中的目的.
主要方法:
- 聘请了制药流行病学家和监管机构的专家小组指导怀孕ACE-IT的开发.
- 开发了一个专注于神经管缺陷作为特定怀孕结果进行评估的图片.
- 利用27个外部评级者来评估一个同行评审的算法,用于使用妊娠ACE-IT识别神经管缺陷.
主要成果:
- 怀孕ACE-IT被大多数评级者认为是可以接受和适当的.
- 一些用户报告了工具易用性带来的挑战.
- 该工具证明了其适用性,灵活性和内容与其预期用途相关.
结论:
- 怀孕ACE-IT是一个合适,灵活,可接受和适当的工具,用于评估怀孕结果算法的适应性,以适应特定的决策环境.
- 未来的工作应该集中在提高用户友好性和扩大接受度.
- 需要进行进一步的研究,以评估该工具在各种妊娠/分娩结果和治疗领域的适用性.
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