3'-C-扩展的TNA:De Novo合成,增强的外核酶阻力和功能性siRNA 3'-超悬浮修饰而不影响基因沉默

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Updated: Sep 11, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Substrate Generation for Endonucleases of CRISPR/Cas Systems

Published on: September 8, 2012

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Yihang Gao1,2, Chenghe Xiong1, Chunlei Zhang3

  • 1Shenzhen Key Laboratory of Synthetic Genomics, Guangdong Provincial Key Laboratory of Synthetic Genomics, State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

Chemistry (Weinheim an der Bergstrasse, Germany)
|August 18, 2025
PubMed
概括

新型三核酸 (TNA) 相似物增强小干扰RNA (siRNA) 对核酶的稳定性. BpioNA的修改抵抗了降解,维持了长期RNA干扰 (RNAi) 疗法的基因沉默.

关键词:
3′过悬的部分.化学修饰是一种化学修饰.siRNA 是一个RNA.异核酸 (XNA) 是一种核酸.

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