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将内在的大脑功能障碍与PTSD症状的战斗暴露男性的行为结果联系起来

Deborah L Harrington^1,2, Qian Shen^1,2, Annemarie Angeles-Quinto^1,2

¹Department of Radiology, University of California, San Diego, San Diego, CA, United States.

Frontiers in psychiatry

|August 18, 2025

概括

患有PTSD的退伍军人表现出异常的大脑活动,特别是在影响情绪调节和执行功能的区域. 这些神经生物学变化与症状严重程度和认知障碍有关,为持续残疾提供了洞察力.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

创伤暴露可能导致异常的内在大脑活动,但它与与压力相关的症状和同时发生的精神和认知变化的联系尚不清楚.
了解患有创伤后应激障碍 (PTSD) 的战斗人员持续残疾的神经行为机制对于有效治疗至关重要.

研究的目的:

研究男性战斗暴露军事人员和退伍军人患有PTSD (CE-PTSD) 症状的持续残疾背后的神经行为机制.
在CE-PTSD中识别大脑内在活动的障碍及其与压力,精神症状和认知功能相关的关系.

主要方法:

休息状态fMRI用于量化CE-PTSD患者 (n=19) 和受创伤暴露的对照 (n=24) 的区域同质性 (ReHo) 和低频波动的分数幅度 (fALFF).
测量皮层厚度和灰色/白质体积,以评估宏观结构变化.
分析了区域大脑异常和行为指标 (症状严重程度,认知功能) 之间的相关性.

主要成果:

脑后应激障碍 (CE-PTSD) 没有显示大脑结构的显著变化,但在前面的胰岛/极和副海马体呈现出增加的fALFF,并在下环中减少了ReHo.
在右前面的胰岛/极增加的fALFF与更高的过度兴奋和冲动性相关.
在右侧副海马体增加的fALFF与较低的过度兴奋和抑郁相关,这表明了适应性反应;区域异常影响了执行功能.

结论:

一种无偏见的成像方法确定了CE-PTSD的内在大脑功能障碍核心,影响情绪调节和认知.
这些神经生物学发现为患有CE-PTSD的个体提供了对功能能力和心理治疗反应能力的见解.
需要更大的样本大小来验证这些关于CE-PTSD中大脑功能障碍的初步结果.

关键词:

这里是ReHoHo的房间.认知功能认知功能法尔夫夫夫 (法尔夫夫夫) 的意思创伤后应激障碍创伤后应激障碍精神病的症状精神病的症状休息状态的功能性MRI.压力症状压力症状

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