在患有呼吸道同胞病毒感染的儿童中,早期发现复发性喘息风险
Ying Wang1, Yalin Shi2, Lijuan Wang2
1Department of Pediatric Cardiovascular and Respiratory Medicine, Xianyang Rainbow Hospital Xianyang 712000, Shaanxi, China.
American journal of translational research
|August 18, 2025
概括
周围血液中乙氨基细胞 (EOS) 计数和鼻中的特定细菌可以预测呼吸道同胞病毒 (RSV) 下呼吸道感染后儿童的复发性喘息. 这有助于早期风险评估,以便更好地进行干预.
科学领域:
- 儿科肺病学 儿科肺病学
- 微生物组研究 微生物组研究
- 传染性疾病 传染性疾病
背景情况:
- 呼吸系统综合体病毒 (RSV) 感染后的复发性喘息发作对儿科呼吸系统健康构成重大挑战.
- 识别复发性喘息的可靠预测因素对于及时干预和管理至关重要.
研究的目的:
- 评估外周血液中乙酸氨基细胞 (EOS) 计数和鼻微生物群在RSV下呼吸道感染后儿童中对复发性喘息的预测能力.
- 开发和验证一次性喘息的预测模型.
主要方法:
- 对614名RSV感染儿童进行了回顾性分析,对164名儿童进行了外部验证.
- 收集临床数据,血液学参数和鼻菌群的个人资料.
- 后勤回归和接收机运行特征 (ROC) 曲线分析用于模型开发和验证.
主要成果:
- 周围血液中EOS数量,血清25(OH) D和IgM水平,以及特定的鼻细菌 (Streptococcus pneumoniae,Haemophilus influenzae) 与复发性喘息显著相关.
- 开发的预测模型表明诊断性能中等至良好 (AUC = 0.747),外部验证 (AUC = 0.741).
结论:
- 周围血液EOS数量和鼻微生物群组成是RSV感染后复发性喘息的关键预测因素.
- 预测模型为早期风险分层和个性化干预提供了潜力,以防止儿科患者的复发性喘息.
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