血硫化作为急性缺血性中风中附带大脑循环的有希望的预测因子
Haiyan Chen1,2,3, Jianmin Huang2, Pin Zheng4
1The First Clinical Medical College of Jinan University Guangzhou 510000, Guangdong, China.
American journal of translational research
|August 18, 2025
概括
血硫化 (H2S) 水平是急性缺血性中风 (AIS) 患者良好的附带循环的强有力的指标. 较高的H2S与更好的结果相关,并且可以预测中风后血流改善.
科学领域:
- 神经学 神经学
- 生物化学 生化学
- 心血管研究研究心血管研究
背景情况:
- 附带循环对于减轻急性缺血性中风 (AIS) 损伤至关重要.
- 硫化 (H2S) 是一种具有潜在的血管保护作用的内源性气传递物.
- 了解影响AIS附带形成的因素对于改善患者的治疗结果至关重要.
研究的目的:
- 检查血硫化 (H2S) 水平与AIS患者的附带循环之间的关联.
- 为了研究血管内皮生长因子 (VEGF),同型半氨酸 (Hcy) 和B族维生素 (叶酸[FA],B12,B6) 在这种关系中的作用.
- 确定H2S是否可以作为预测AIS中的抵押品发展的生物标志物.
主要方法:
- 68名AIS患者被分为良好的附带循环 (GCC) 和不良的附带循环 (PCC) 组.
- 血中H2S,VEGF,Hcy,FA,VB12和VB6的度使用微试验和ELISA在治疗后的第2天和第7天进行测量.
- 临床严重程度使用国家卫生研究院中风量表 (NIHSS) 和修改的兰金量表 (mRS) 进行评估.
主要成果:
- 与PCC组相比,GCC组的NIHSS和mRS得分明显较低.
- 在GCC组的患者的血H2S,VEGF,FA,VB12和VB6水平显着更高,在两个测量日的Hcy水平更低 (P <0.05).
- 血H2S水平与附带循环,VEGF,FA,VB12和VB6正相关,与Hcy负相关 (P<0.001). H2S显示了对抵押品流通的高预测值 (AUC = 0.943).
结论:
- 血H2S水平与AIS患者良好的附带循环的发展有显著的关联.
- H2S,与VEGF和B族维生素一起,在调节附带形成方面发挥作用,而Hcy似乎有相反的关系.
- 血H2S水平升高可能成为急性缺血性中风中良好的附带循环的有价值的预测生物标志物.
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