评估IL-17A和IL-17F多态与骨关节炎风险的关联:系统性审查和元分析
1College of Nursing, Chengdu University of Traditional Chinese Medicine No. 1166, Liutai Avenue, Wenjiang District, Chengdu 611137, Sichuan, China.
American journal of translational research
|August 18, 2025
概括
介素-17F (IL-17F) 基因多态性与骨关节炎 (OA) 风险有关,特别是在亚洲人群中. 在这次元分析中,介素-17A (IL-17A) 基因多态性与OA风险没有显著关联.
科学领域:
- 遗传学 遗传学是一种遗传学.
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 骨关节炎 (OA) 是一种普遍存在的退行性关节疾病.
- 遗传因素,包括基因多态性,都涉及到OA的发病.
- 介素-17 (IL-17) 细胞因子在炎症和免疫反应中起作用,可能会影响OA的发展.
研究的目的:
- 系统地审查和元分析17A介质素 (IL-17A; rs2275913) 和17F介质素 (IL-17F; rs763780) 基因多态和骨关节炎 (OA) 风险之间的关联.
- 调查这些协会中潜在的种族差异.
主要方法:
- 发表的研究的系统审查和元分析.
- 搜索电子数据库,查找2014年至2019年间出版的相关报告.
- 包括与病例控制组分析亚洲和高加索人群IL-17A和IL-17F多态性的研究.
主要成果:
- 对IL-17A (rs2275913) 的分析显示,在总人口或种族小组中,与OA风险没有显著的相关性 (P > 0.77).
- 对IL-17F (rs763780) 的分析显示,在整体人群中,与OA风险有显著的关联 (P < 0.0001).
- 种族子组分析表明,IL-17F与亚洲人中的OA有关,在高加索人中通过等位基因和主导模型与OA有关. 亚洲人群表现出更高的敏感性.
结论:
- IL-17F基因多态性是OA的重要危险因素,在不同种族群体中易受影响.
- IL-17A基因多态性与OA风险没有关联.
- 进一步的研究可能会阐明IL-17F在OA病变发生过程中的具体机制.
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