与呼吸道同胞病毒预流F (RSVpreF) 相关的副作用 孕产妇疫苗接种:一个范围审查
Mabel Palmero1, Roberto A Martin1, Benjamin Olson1
1Family Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.
Cureus
|August 18, 2025
概括
用于孕妇的Pfizer RSVpreF疫苗表现出良好的耐受性与轻微的副作用. 需要更多关于妊娠高血压疾病和长期母亲健康结果的潜在联系的研究.
科学领域:
- 免疫学 免疫学 免疫学
- 孕产妇健康 孕产妇健康
- 疫苗学 疫苗学 疫苗学
背景情况:
- 呼吸道同胞病毒 (RSV) 是婴儿呼吸道疾病的主要原因之一.
- 用PfizerRSVpreF疫苗对母亲进行免疫接种是保护新生儿的一种策略.
- 关于怀孕期间这种疫苗对母亲的安全结果的数据是有限的.
研究的目的:
- 审查怀孕期间瑞RSVpreF疫苗对孕妇安全性和副作用的现有证据.
- 发现当前关于疫苗接种后母亲健康结果的研究中的差距.
主要方法:
- 在六个数据库 (MEDLINE,Embase,CINAHL,Cochrane,Web of Science,ClinicalTrials.gov) 进行系统搜索,从2020年1月到2024年9月进行研究.
- 包括专注于在怀孕期间接种RSVpreF疫苗后母亲的结果的研究.
- 使用Joanna Briggs Institute (JBI) 方法来进行范围审查的数据提取和分析.
主要成果:
- 五项研究符合纳入标准,包括RCT和一项回顾性队列研究.
- 一般来说,RSVpreF疫苗的耐受性很好,常见的副作用是注射部位反应.
- 不一致的不良事件报告,如先兆子和妊娠高血压; 一项研究表明,可能与妊娠高血压障碍 (HDP) 有不确定的联系.
结论:
- 瑞公司的RSVpreF疫苗对于孕妇来说似乎是安全的,通常有轻微的副作用.
- 需要进一步的研究来弥补孕产妇安全数据的差距,特别是关于HDP和长期结果.
- 未来的研究应该包括多样化的群体,并专注于全面的安全评估,以获得公平的疫苗接种.
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