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创新的生物标志物用于诊断肝癌中的恶性瘤

Yan Zhang¹, Jing Wu¹, Huaizhong Cui¹

¹Department of Clinical Laboratory, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.

OncoTargets and therapy

|August 18, 2025

概括

高光细胞 (HF-BF%),癌症比率2 (Ratio2) 和神经元特异性酶 (NSE) 可以帮助预测肝癌中的恶性瘤. 这些标记物的结合为这种常见并发症提供了高的诊断准确度.

科学领域:

在瘤学瘤学.
诊断医学诊断医学
生物化学生物化学

背景情况:

肝癌是全球癌症相关死亡的主要原因之一.
转移性恶性炎是肝癌的常见和严重并发症.
准确预测恶性炎对于及时干预和改善患者结果至关重要.

研究的目的:

评估高光细胞 (HF-BF%),癌症比率2 (Ratio2) 和神经元特异性酶 (NSE) 在预测肝癌患者转移性恶性炎的诊断意义.
为了比较这些标记单独和组合的诊断准确性.

主要方法:

从266名肝癌患者中采集了样.
使用血液学分析仪 (HF-BF%) 分析高光细胞 (HFC).
生物化学标记物 (Ratio2) 和瘤标记物 (NSE) 在血清和瘤中被测量.
用接收器操作特征 (ROC) 曲线分析来评估诊断准确性.

主要成果:

与良性炎相比,恶性炎患者的HF-BF%,Ratio2和NSE水平显著更高.
HF-BF% (AUC=0.760) 和NSE (AUC=0.700) 显示出适度的诊断能力.
对HF-BF%,Ratio2和NSE的综合评估实现了高诊断能力 (AUC=0.824).

结论:

HF-BF%,Ratio2和NSE的组合是预测肝癌中转移性恶性炎的宝贵工具.
这些标记物可以帮助早期识别患有恶性瘤风险的患者.
进一步的研究可能会在临床实践中完善这些标记物的使用.

关键词:

在NSE NSE中,我们可以看到NSE.亚酸 LDH:亚酸 ADA 的比率.高光细胞是一种高光细胞.肝癌肝癌是一种肝癌.恶性腰炎是一种恶性腰炎.

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