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胰岛素耐药性,与代谢功能障碍相关的脂肪性肝病,以及美国瘦肉成年人的晚期肝纤维化:基于人口的研究
Basile Njei1, Manasik Abdu2, Yazan A Al-Ajlouni3
1Section of Digestive Diseases, Yale University School of Medicine, New Haven, Connecticut, USA.
Proceedings (Baylor University. Medical Center)
|August 18, 2025
概括
胰岛素抵抗 (IR) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和瘦肉成年人肝纤维化有关. 早期对IR的评估可以帮助识别有风险的个体,即使没有糖尿病.
科学领域:
- 代谢健康 代谢健康
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 胰岛素抵抗 (IR) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 在肥胖中很常见,但在瘦个体中研究较少.
- 在非肥胖人群中,IR和MASLD之间的关系需要进一步研究.
研究的目的:
- 在瘦身成年人中调查IR和MASLD之间的关联.
- 在稀疏人群中探索IR和晚期肝纤维化之间的联系.
主要方法:
- 使用美国国家健康和营养检查调查 (2017-2020) 数据进行的横截面研究.
- 包括没有病毒性肝炎,艾滋病毒,过度饮酒或糖尿病的瘦身成年人 (亚洲人BMI<25 kg/m2或<23 kg/m2).
- 使用过渡性弹性学,HOMA-IR,QUICKI和HOMA-β来评估肝脂肪,IR和β细胞功能.
主要成果:
- 在瘦身成年人中,MASLD的患病率为8.9%.
- 胰岛素耐药性测量 (HOMA-IR,QUICKI) 和β细胞功能 (HOMA-β) 与MASLD有显著的关联.
- 在这个瘦肉队列中,HOMA-IR也与晚期肝纤维化有关.
结论:
- 瘦个体中MASLD和晚期肝纤维化与胰岛素抵抗有关,独立于整体脂肪.
- 评估IR可能有助于识别患MASLD和肝纤维化风险较高的瘦人,无论他们的糖尿病状况如何.
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