与氧化应激和脂质失调相关的患者心血管风险
Vesna Karanikolic1, Mirjana Bakic2, Sanja Gluscevic3
1University of Nis-School of Medicine, Clinic for Skin Diseases of the Clinical Center Nis, Nis.
Journal of medical biochemistry
|August 18, 2025
概括
牛皮患者患有更高的心血管疾病风险,与炎症和氧化应激有关. 三甘油 (TG) 独立预测这些患者的动脉样硬化心血管疾病 (ASCVD) 风险评分,强调监测TG水平的重要性.
科学领域:
- 心脏病学 心脏病学
- 皮肤病学 皮肤病学
- 生物化学 生物化学
背景情况:
- 牛皮患者表现出高心血管疾病 (CVD) 风险.
- 牛皮和动脉样硬化之间的共享病原包括炎症和氧化应激.
- 非传统的生物标志物和传统的代谢参数对于评估牛皮中心血管疾病风险至关重要.
研究的目的:
- 为了研究牛皮患者的心血管风险.
- 检查心脏病风险与非传统生物标志物 (氧化应激,炎症) 和传统代谢参数之间的关联.
- 为了确定动脉样硬化心血管疾病 (ASCVD) 风险评分在牛皮中的预测因素.
主要方法:
- 分析了68名牛皮患者.
- 测量了传统的代谢参数,氧化应激标志物 (AOPP,MDA,CAT,SOD) 和C反应蛋白.
- 计算ASCVD风险评分,并将患者分为三分之一.
主要成果:
- 较高的ASCVD得分与较低的HDL-C,较高的甘油三 (TG) 和较高的TG/HDL-C比率相关.
- 氧化蛋白产品 (AOPP) 与ASCVD得分增加.
- 在多变量分析中,甘油三 (TG) 被确定为ASCVD风险评分的独立预测因子.
结论:
- 牛皮患者显示ASCVD得分,氧化应激 (AOPP) 和脂质失调 (TG) 之间的关联.
- 甘油三 (TG) 是ASCVD风险评分的唯一独立预测因素.
- 监测血清TG水平对于管理牛皮患者心血管风险至关重要.
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