在急性声学创伤后,鼻分泌物中的细胞因子变化
Vanja Jovanović1, Sonja Marjanović1, Aleksandar Perić1
1University of Defence, Military Medical Academy, Faculty of Medicine, Belgrade.
Journal of medical biochemistry
|August 18, 2025
概括
接触枪支会导致听力损失,并增加鼻子前炎性细胞因子,特别是在男性中. 这项研究将声学创伤与军事学员在枪支训练后的细胞因子水平升高联系在一起.
科学领域:
- 军队的医疗卫生.
- 听觉科学是一种听觉科学.
- 免疫学 免疫学 免疫学
背景情况:
- 职业噪音引起的听力损失是一个很大的风险,特别是对军人来说.
- 枪声的冲动噪声会导致严重的,立即的听力损失.
- 这项研究调查了接触枪支的军校学员中神经传感器听力损失和细胞因子水平.
研究的目的:
- 探索传感神经听力损失和鼻分泌中的细胞因子水平之间的关系.
- 评估高强度枪声暴露对军事学员的影响.
- 为了比较男性和女性参与者之间的这些影响.
主要方法:
- 105名19-25岁的学员 (75名男性,30名女性) 接受了枪支训练.
- 进行了听力测试.
- 在三个时间点,分析了鼻子分泌物中的介乐金-1β (IL-1b),瘤坏死因子-α (TNF-a),粒细胞巨菌殖民地刺激因子 (GM-CSF) 和介乐金-10 (IL-10).
主要成果:
- 39%的男性和21%的女性经历了声学创伤后的听力损伤.
- 在那些有听力变化的患者中,IL-1b水平在暴露后立即增加.
- 24小时后,IL-1b和GM-CSF水平仍然升高,所有参与者都观察到显著的变化,特别是那些有听力图变化的参与者.
结论:
- 导致听力损失的声学创伤与增加的鼻子前炎性细胞因子有关.
- 声学创伤对细胞因子水平的影响在男性中比女性更为明显.
- 研究结果突出了军人群体对噪音引起的听力损失的炎症反应.
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