在双连续微乳液中封装的格拉米西丁和赫西丁:抗微生物活性性能及其对自组装的影响
Douglas G Hayes1, Riley Arp2, Doris H D'Souza2
1University of Tennessee, Departments of Biosystems Engineering and Soil Science, 2506 E.J. Chapman Drive, Knoxville, TN 37996-4531 USA.
Journal of surfactants and detergents
|August 18, 2025
概括
双连续微乳液 (BME) 有效地携带了用于局部施用的抗菌和消毒剂. 然而,这些活性剂改变了BME结构,影响了对耐药细菌的整体抗菌疗效.
科学领域:
- 合体和表面科学科学
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 抗微生物 (AMP) 和消毒剂对于对抗抗生素耐药细菌至关重要.
- 双连续微乳液 (BMEs) 作为局部应用的输送系统具有潜力.
- 了解活性剂和BME结构之间的相互作用对于配方疗效至关重要.
研究的目的:
- 研究BME作为格拉米西丁D (AMP) 和赫西丁 (消毒剂) 的载体的实用性.
- 探索这些因素对BME结构和动态的影响.
- 评估BME配方对皮肤相关细菌的抗菌疗效.
主要方法:
- 在各种系统中,用格拉米西丁D和赫西丁配制BME.
- 使用小角度中子散射 (SANS) 进行BME结构和动态的表征.
- 在人造皮肤上进行生物测试,以评估对抗生素耐药细菌的抗菌活性.
主要成果:
- 格拉米西丁D和赫西丁在显著度下成功地被纳入了BME.
- 这两种溶液都改变了BME的界面性质,降低了表面活性剂的活性,增加了在一个系统中的流动性,而在其他系统中形成聚合物.
- 含有活性剂的BME配方显示出对细菌的增强生物活性,尽管在一些试验中,整体疗效低于水性对照.
结论:
- 抗微生物和消毒剂显著影响BME结构和动态.
- 复杂的相互作用需要谨慎的配方策略,以通过BME提供最佳的抗微生物药物.
- 需要进一步的研究来优化BME配方以提高局部抗菌活性.
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