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患有肺结核和非结核下呼吸道感染的儿童的肺功能轨迹

I J Courtney¹, M Palmer¹, R Swanepoel²

¹Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.

|August 18, 2025

概括

与对照组相比,患有肺结核 (TB) 和非TB下呼吸道感染 (LRTI) 的儿童在一年内显示出类似的肺功能下降,结核患者的强迫生命能力 (FVC) 降低.

科学领域:

儿科肺病学儿科肺病学
传染性疾病传染性疾病
呼吸系统医学呼吸系统医学

背景情况:

长度研究比较儿科肺结核 (PTB),非结核性下呼吸道感染 (LRTI) 和健康对照的肺功能.
研究了受结核病和其他呼吸道疾病影响的儿童的长期呼吸道健康结果.

研究的目的:

在52周的时间内,将被诊断为PTB的儿童的肺功能轨迹与非TB的LRTI和健康对照进行比较.
评估PTB和LRTIs对儿童肺功能参数的影响.

主要方法:

包括4至13岁能够进行螺旋计的儿童,结核病,非结核病LRTIs和健康对照组.
螺旋测量 (FEV1,FVC,FEV1/FVC) 在基线和超过52周使用全球肺部倡议参考范围进行.
根据对结核病和非结核病LRTIs的仔细评估和随访对儿童进行分类.

主要成果:

分析了143名儿童 (46名结核病患者,64名非结核病患者LRTIs,33名对照患者);7%的儿童感染了艾滋病毒.
在随访后的两个症状组中,限制性螺旋测量模式普遍存在.
结核病和非结核病LRTI组都显示FEV1和FVC与对照组相比降低,结核病组的FVC显著降低.

结论:

在患有PTB和非TB的儿童中,肺功能轨迹与LRTIs相似.
患有PTB和非TB的LRTIs的儿童在诊断后一年表现出强迫生命能力 (FVC) 降低.

关键词:

这是一个 PTLD.与结核病相关的呼吸道发病率.在儿童结核病的治疗中.螺旋测量是一种螺旋测量.结核病是一种肺结核病.

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