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Updated: Sep 11, 2025

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对TRIM家族PRYSPRY域的结构分析及其对E3联体设计的影响

Rezart Zhubi1,2, Apirat Chaikuad1,2, Christian J Muñoz Sosa1,2

  • 1Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany.

Journal of structural biology: X
|August 18, 2025
PubMed
概括

三分 motif (TRIM) 蛋白质,关键的 E3 无素连接酶,具有 PRYSPRY 域,结构保留,但结合点不同. 这种结构多样性影响基质的特异性,并为开发针对这些TRIM蛋白的新药提供了潜力.

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