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M1巨细胞 - - 对瘤进展有意想不到的贡献

Olga V Kovaleva¹, Madina A Rashidova¹, Vasiliy V Sinyov¹

¹Institute of Carcinogenesis, N. N. Blokhin National Medical Research Center of Oncology, Moscow, Russia.

Frontiers in immunology

|August 18, 2025

概括

细胞毒性M1巨细胞,虽然最初与瘤作斗争,但矛盾的是,可以通过选择耐药细胞来促进癌症的进展. 新的免疫疗法必须考虑这种复杂的作用,以获得更好的结果.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
癌症生物学癌症生物学

背景情况:

免疫系统,特别是干扰素γ激活细胞,在抗瘤免疫中起着至关重要的作用.
瘤免疫编辑描述了免疫系统和癌细胞之间的动态相互作用,影响瘤进化.
巨细胞,自然杀手细胞和T淋巴细胞是抗瘤反应的关键参与者,M1巨细胞传统上与瘤根除有关,M2巨细胞与免疫抑制有关.

研究的目的:

为了检查M1巨细胞在抗瘤免疫中的复杂,上下文依赖的功能.
重新评估目前的治疗策略,重点是增强M1巨细胞毒性.
提出免疫疗法设计的范式转变,考虑到巨细胞可塑性和瘤动态.

主要方法:

对现有的关于巨细胞两极分化和癌症中的功能文献的综述.
对瘤免疫编辑过程和免疫压力的分析.
检查M1巨细胞在瘤进展中的矛盾作用.

主要成果:

最初具有细胞毒性的M1巨细胞可以无意中促进瘤的进展.
来自M1巨细胞的持续细胞毒性压力选择了更多的恶性和免疫抵抗性瘤克隆.
目前增强M1细胞毒性的策略可能会加快瘤进化和免疫规避的风险.

结论:

对M1和M2巨细胞的二进制观点是不够的;它们的作用取决于上下文.
治疗策略应该超越仅仅促进M1两极分化.
对巨细胞可塑性和瘤动态的细微理解对于开发有效的免疫疗法至关重要,以避免意外支持瘤进化.

关键词:

ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC ADCC is also known as ADCC ADCC ADCC is also known as ADCC 在ADCP中,ADCP是ADCP.免疫疗法免疫疗法这是一种炎症炎症炎症炎症.这是先天免疫力.巨细胞是一个巨细胞.瘤是一个瘤.

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