在年轻和大师运动员中,对急性运动和ex vivo免疫挑战的不同炎症反应
Luciele Guerra Minuzzi1,2,3, Alexandre Abilio De Souza Teixeira4, Caique Figueiredo1
1Exercise and Immunometabolism Research Group, Postgraduation Program in Movement Sciences, Department of Physical Education, Universidade Estadual Paulista "Julio de Mesquita Filho", Sao Paulo, Brazil.
Frontiers in immunology
|August 18, 2025
概括
年轻的运动员表现出较高的炎症反应刺激相比,主体运动员,谁表现出一个更受调节的免疫特征. 运动在不同年龄段对这些反应产生不同的影响.
科学领域:
- 免疫学 免疫学 免疫学
- 运动生理学 运动生理学
- 衰老研究研究 衰老研究
背景情况:
- 终身炼对免疫系统有好处,但其对急性炎症挑战的影响尚未完全理解.
- 研究运动适应如何影响不同年龄的运动员的免疫反应至关重要.
研究的目的:
- 为了比较年轻和大师运动员对ex vivo免疫挑战的炎症反应.
- 评估单次中等强度运动对这些炎症反应的影响.
主要方法:
- 来自年轻 (22 ± 4岁) 和大师 (52 ± 9岁) 运动员的全血和外围血液单核细胞 (PBMC) 被培养.
- 培养物用脂多糖 (LPS) 或醇12-米酸13-乙酸 (PMA) 以及ionomycin刺激.
- 细胞因子 (IL-6,TNF-α,IFN-γ) 的产生在30分钟中等强度运动前后进行测量.
主要成果:
- 年轻运动员与主体运动员相比,LPS诱导的INTERLEUKIN-6 (IL-6) 和瘤坏死因子-α (TNF-α) 释放量显著增加.
- 主体运动员表现出从PBMCs中释放的TNF-α较低,仅在运动后观察到增加.
- 在年轻运动员中,PMA/ionomycin刺激显示TNF-α和干扰因子- (IFN-γ) 释放量更大,在年轻运动员中 IL-6 减少.
结论:
- 年轻运动员表现出更强大的细胞因子对炎症刺激的反应.
- 主体运动员具有更受控制和调节的炎症特征,这表明与年龄相关的免疫调节.
- 运动影响炎症反应,在年轻和大师运动员之间观察到不同的模式.
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