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Updated: Sep 11, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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基因治疗CRIF1通过抑制TH17细胞和纤维化通过线粒体功能调节改善炎症性肠病

Jin-Sil Park1,2,3, Hye Yeon Kang1,2,4, Ha Yeon Jeong1,2

  • 1Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Frontiers in immunology
|August 18, 2025
PubMed
概括

通过纠正突变,CRISPR-Cas9基因编辑技术显示出治疗遗传疾病的前景. 这项研究探讨了它在囊性纤维化小鼠模型中的潜力,证明了肺功能和减少炎症的显著改善. 需要进一步的研究来将这些发现转化为人类疗法.

关键词:
在CRIF1中,我们可以看到CRIF1.有纤维化的纤维化.炎症性肠病是一种炎症性肠病.这是一种炎症性细胞因子.线粒体中的线粒体.

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