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辛提利马布诱导的肠道阻塞和消化道出血:一个病例报告
Qian Hao1, Wenwen Zhu2, Qingqing Guo3
1Department of General Practice, Shandong Provincial Third Hospital, Shandong, Jinan, China.
Frontiers in immunology
|August 18, 2025
概括
免疫检查点抑制剂 (ICI) 可以引起诸如免疫媒介性结肠炎之类的不良反应. 这份病例报告详细介绍了一名患者在治疗晚期癌症的辛提利马布治疗期间出现了状.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 胃肠病学 胃肠病学
背景情况:
- 免疫检查点抑制剂 (ICI) 在癌症治疗中至关重要.
- 包括免疫媒介性结肠炎 (IMC) 在内的不良反应是ICI的一个问题.
- 消化管胃节状细胞癌 (IVB阶段) 需要多式治疗.
研究的目的:
- 在患有晚期食管胃结平细胞癌的患者中报告Sintilimab诱导的状的病例.
- 为了提高临床理解和管理与sintilimab相关的不良反应.
- 为了指导在癌症治疗中合理使用sintilimab.
主要方法:
- 一个67岁的男性患者的病例报告,患有IVB期食管胃结状细胞癌.
- 患者接受了化疗,向治疗和免疫疗法 (sintilimab).
- 通过结肠镜检查和病理活检证实了多重头骨的诊断.
主要成果:
- 患者经历了肠道阻塞,腹痛和下消化道出血.
- 鉴定出多个头骨的是症状的原因.
- 这些症状归因于sintilimab治疗.
结论:
- 辛提利马布可以引起严重的胃肠道不良反应,如状.
- 对于接受ICI治疗的患者来说,早期识别和适当的治疗是必不可少的.
- 这一案例凸显了监测和管理ICI相关毒性的重要性.
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