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Updated: Apr 29, 2026

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刺激响应的寡聚氨酸-PEG涂层用于减少触发的解复.

Hugo J Rodríguez-Franco1, Artem Kononenko1, Maartje M C Bastings1

  • 1Programmable Biomaterials Laboratory, Institute of Materials, Interfaculty Bioengineering Institute, School of Engineering, Ecole Polytechnique Fédérale Lausanne, Lausanne 1015, Switzerland.

ACS polymers Au
|August 18, 2025
PubMed
概括

响应性DNA原始素纳米粒子 (DON) 使用可切割的寡聚氨酸-PEG涂层开发. 这些涂层在生理条件下保护DONs,并在细胞中释放它们.

关键词:
DNA原始化纳米粒子的原始化生物界面生物界面减少性去保护 减少性去保护稳定涂层的稳定涂层.对刺激有反应的聚合物.

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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