在老年MHD患者的认知虚弱方面,开发一种基于拉索-诺摩图的风险预测模型
Ning-Ning Xia1, Jing Liu1, Hongying Wang1
1Blood Purification Center, Nanjing BenQ Medical Center, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
Neuropsychiatric disease and treatment
|August 18, 2025
概括
认知虚弱影响38.1%的接受维持血液透析 (MHD) 的老年人. 一种新的诺莫格拉姆模型有效地识别了高风险患者的早期干预.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 老年病的医生 老年病的医生
- 认知科学 认知科学
背景情况:
- 在接受维持血液透析 (MHD) 的老年人中,认知虚弱是越来越令人担忧的.
- 现有的查工具对于这个特定的患者群体是不够的.
- 早期识别对于及时干预和改善结果至关重要.
研究的目的:
- 开发一种预测模型,用于识别具有高认知脆弱风险的老年MHD患者.
- 促进MHD患者认知虚弱的早期发现和个性化干预.
主要方法:
- 一项涉及223名老年MHD患者的横截面研究.
- 数据收集包括临床特征和标准化的认知/脆弱性评估.
- 最小绝对收缩和选择运算符 (LASSO) 和多变量后勤回归被用来识别风险因素并构建预测性名录.
主要成果:
- 认知虚弱的患病率为38.1% (85/223名患者).
- 鉴定了八个独立的危险因素:血清,血红蛋白,抑郁症评分,认知储备,年龄,透析持续时间,透析充分性 (Kt/V) 和静脉透析性低血压.
- 诺米图表显示出优异的预测性能 (AUC 0.986),具有高灵敏度 (94.9%) 和特异性 (97.6%).
结论:
- 在老年MHD患者中,认知虚弱非常普遍.
- 开发的诺米图是早期查和个性化干预的实用工具.
- 这个模型有助于管理这个脆弱人群的认知健康.
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