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儿童急性淋巴细胞白血病幸存者的骨矿物质密度及其影响因素
Sanjeev Khera1, Jasdeep Singh2, Amit Kumar3
1Professor (Paediatrics) & Paed Hemato-Oncologist, Army Hospital (R&R), Delhi Cantt, India.
Medical journal, Armed Forces India
|August 18, 2025
概括
儿童急性淋巴细胞白血病 (cALLS) 幸存者显示出低骨矿物质密度 (BMD) 的高患病率. 然而,在这些幸存者中,增加脂肪似乎有助于保护低BMD.
科学领域:
- 儿科瘤学 儿科瘤学
- 骨的新陈代谢 骨的新陈代谢
- 幸存者研究研究 幸存者研究
背景情况:
- 关于儿童急性淋巴细胞白血病 (cALLS) 幸存者的骨健康存在相互矛盾的文献.
- 大多数研究表明,cALLS对骨矿物质密度 (BMD) 有不利影响.
研究的目的:
- 研究影响儿童急性淋巴细胞白血病 (cALLS) 幸存者的骨矿物密度 (BMD) 的因素.
- 确定低BMD的患病率,并确定相关的人口,治疗,疾病相关和内分泌因素.
主要方法:
- 7岁以上cALLS的横截面研究.
- 使用双能X射线吸收计 (DEXA) 测量骨矿物质密度 (BMD),用于腰部神经 (LS-BMD) 和全身 (WB-BMD).
- 低BMD定义为LS-BMD ≤2z-score;分析低与正常BMD组中的影响因素.
主要成果:
- 25%的cALLS (15/59) 呈现低LS-BMD;5% (3/59) 具有低WB-BMD.
- 在多变量分析中,高脂肪与正常的骨质量 (OR5.2,p=0.01) 有显著的关联.
- 诊断时的年龄>10年与低BMD相关 (p=0.02);荷尔蒙和矿物质测定在组之间是可比的.
结论:
- 在这组儿童急性淋巴细胞白血病幸存者 (cALLS) 中,观察到低腰部神经骨矿物质密度 (LS-BMD) 的高患病率.
- 增加脂肪被确定为对低BMD的保护因素,与预期相反.
- 证实了LS-BMD和WB-BMD之间的显著相关性.
关键词:
急性淋巴细胞白血病 (Acute Lymphoblastic Leukemia) 是一种急性淋巴细胞白血病.骨矿物质密度 骨矿物质密度儿童白血病幸存者儿童白血病幸存者德克萨扫描 (DEXA) 扫描可以检查.晚期影响 后期影响更多相关视频
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