MLR对应于慢性淋巴细胞白血病中单细胞的功能状态
Wioleta Grzegorzewska1, Michał Zarobkiewicz1, Katarzyna Jastrzębska-Pawłowska1
1Department of Clinical Immunology, Medical University of Lublin, Lublin 20-093, Poland.
International journal of inflammation
|August 18, 2025
概括
单细胞/淋巴细胞比 (MLR) 可能表明慢性淋巴细胞白血病 (CLL) 的活性和进展. 在CLL患者中,较高的MLR与可能促进疾病负担的特定单细胞变化相关.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 炎症微环境在慢性淋巴细胞白血病 (CLL) 发病和进展中的作用尚不清楚.
- 评估周围血液中的炎症标志物是炎症的系统性指标.
- 需要对CLL患者循环炎症细胞进行详细的分析.
研究的目的:
- 评估单细胞/淋巴细胞比率 (MLR) 与CLL进展风险之间的关系.
- 分析CLL中的MLR是否表明循环单细胞子集的功能性免疫状态.
主要方法:
- 分析了54名未经治疗的CLL患者和20名健康志愿者的外周血液样本.
- 多参数流细胞计评估单细胞子群,包括表面标记物和细胞内细胞因子.
- 相对微RNA表达 (miR-21-3p,miR-150-5p,miR-106a-5p) 在FACS排序的单细胞子集中确定.
主要成果:
- 与健康志愿者相比,CLL患者的MLR值显著较低 (p < 0.0001).
- 在具有负预后因素 (增加ZAP-70和CD38表达) 的CLL患者中观察到较高的MLR.
- 高MLR的CLL患者显示中间单细胞增加和经典/非经典单细胞减少,中间单细胞显示较高的IL-10和较低的miR-150-5p.
结论:
- 该MLR指数可以作为CLL活动的标记,并间接反映单细胞亚群的变化.
- 较高的MLR可能表明中介单细胞的百分比增加,具有潜在的抗炎性质.
- 这些与MLR相关的单细胞变化可能会促进CLL的进展,并恶化预后.
更多相关视频
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
29.6K
10:18From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
13.8K
相关概念视频
01:27Disorders of Leukocytes
1.1K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.1K
01:15Differentiation of Common Myeloid Progenitor Cells
3.3K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.3K