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Updated: Sep 11, 2025

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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由METTL3-介导的m6A修饰稳定RGS1促进瘤发生性和巨细胞M2极化在骨髓瘤中

Zhizhong Liang1, Yuxia Shi1, Mao Wang1

  • 1Department of Bone and Soft Tissue Oncology, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan City, Shanxi Province 030032, China.

Journal of bone oncology
|August 18, 2025
PubMed
概括

调节G蛋白信号传递1 (RGS1) 促进骨髓瘤生长和M2巨细胞两极分化. METTL3稳定了RGS1mRNA,增强了瘤进展和免疫抑制,提供了一个潜在的治疗点.

关键词:
在METTL3中,METTL3是METTL3的第一个类型.巨细胞是一个巨细胞.骨质肉瘤骨质肉瘤是什么一个RGS1系统.m6A 一个很好的.

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