由众包获得的胎盘表观遗传钟:对在产科加速衰老的研究的影响
Gaurav Bhatti1, Herdiantri Sufriyana2,3, Roberto Romero4,5,6
1Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48202, USA.
iScience
|August 18, 2025
概括
新的表观遗传年龄模型显示,胎盘加快衰老与男性的出生体重有关,并且在早产中提供对妊娠年龄较小的新生儿的保护. 这些发现完善了对妇产科表观遗传衰老的理解.
科学领域:
- 生殖生物学 生殖生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 基因组学就是基因组学.
背景情况:
- 表观遗传妊娠年龄加速与产科综合征 (如孕前) 有关.
- 准确而公正的表观遗传年龄模型对于可靠的结论至关重要.
- 现有的模型可能在准确性和校准方面存在局限性.
研究的目的:
- 开发和验证使用胎盘甲基组的新型表观遗传年龄模型.
- 评估胎盘表观遗传衰老与怀孕结果之间的关联.
- 调查胎儿在胎盘表观基因组功能中的性别二态作用.
主要方法:
- 为模型开发策划了1842个公共的胎盘甲基组.
- 从384个怀孕 (正常和复杂) 中生成了新的胎盘甲基组数据.
- 组织了一个盲目的DREAM挑战,用于模型开发和比较.
主要成果:
- 开发了与现有的模型相比较有利的模型准确度,并且更好地校准.
- 表明在早产前中加速表观遗传衰老可能是由于模型工件造成的.
- 发现男性新生儿的加快衰老与降低出生体重百分位相关.
- 观察到过早的加快衰老作为保护对小的妊娠年龄的新生儿,不论胎儿的性别.
结论:
- 新的表观遗传年龄模型为胎盘衰老提供了更好的准确性和校准.
- 重新评估表明,在早产前中加速表观遗传衰老可能是一种建模工件.
- 胎盘表观基因组在胎儿生长和产科结果中起着性别二态的作用.
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