在接受胸腔镜肺切除的患者中,胸部准脊椎阻塞使用脂质体布皮瓦卡因与普通布皮瓦卡因:一项随机对照研究
Zhen Yang1,2, Manman Liu1, Chengyu Wang3
1Department of Anesthesiology, Xiamen Zhongshan Hospital, Fudan University, Xiamen, Fujian, People's Republic of China.
Drug design, development and therapy
|August 18, 2025
概括
在视频辅助胸腔镜手术 (VATS) 后,脂质体布皮瓦卡因 (LB) 与普通布皮瓦卡因 (PB) 相比,提供了更长的疼痛缓解. 虽然整体阿片类药物使用情况相似,但LB改善了恢复得分,并延迟了对止痛的需求.
科学领域:
- 麻醉学和疼痛管理
- 胸部外科手术 胸部外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 在胸部手术疼痛管理中,脂质体布皮瓦卡因对胸部副脊椎阻塞的疗效需要进一步研究.
- 这项研究旨在将脂质体布皮瓦卡因与普通布皮瓦卡因进行比较,用于视频辅助胸腔镜手术 (VATS) 患者的胸部副脊椎阻塞.
研究的目的:
- 评估脂质体布皮瓦卡因与普通布皮瓦卡因在胸部准脊椎阻塞中对VATS疼痛管理的有效性.
- 为了比较两组麻醉剂之间的术后阿片类药物消耗,疼痛评分,恢复质量和第一次止痛请求的时间.
主要方法:
- 一项随机试验,涉及114名接受VATS治疗的成年患者.
- 参与者使用脂质体布皮瓦卡因 (LB) 或普通布皮瓦卡因 (PB) 进行胸部副脊椎阻塞.
- 主要终点是手术后48小时的阿片类药物消耗;次要结局包括疼痛评分,QoR-15和第一次止痛的时间.
主要成果:
- 在手术后48小时内,LB和PB组之间的阿片类药物消费没有显著差异.
- 脂质体布皮瓦卡因组显示显著更高的恢复质量-15 (QoR-15) 评分和更长的时间到第一次止痛要求.
- 在LB组观察到休息时疼痛得分减少;然而,咳和慢性术后疼痛的疼痛得分没有差异.
结论:
- 脂质体布皮瓦卡因在VATS患者的胸部副脊椎阻塞方面显示出有限但临床相关的益处.
- 这些发现表明,使用脂质体布皮瓦卡因可以改善康复和延迟止痛需求,尽管整体阿片类药物消费相似.
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