揭示Lactobacillus johnsonii在消化系统疾病中的潜力:一个全面的审查
Jinjie Zhou1,2,3, Shuang Ma1,2,3, Zhuo Huang1,2,3
1Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
Frontiers in microbiology
|August 18, 2025
概括
一种益生菌Lactobacillus johnsonii通过改善免疫力和屏障功能来增强肠道健康. 它在治疗消化系统疾病和维持肠-器官轴平衡方面显示出潜力.
科学领域:
- 微生物学和免疫学
- 胃肠病学 胃肠病学
- 神经科学是一个神经科学.
背景情况:
- 牛乳杆菌约翰尼 (L. johnsonii) 是一种益生菌,以产生乳酸而闻名.
- 它调节肠道微生物群,可能增强免疫功能并降低感染风险.
- 新兴的研究强调了它对胃,肠道,肝脏和大脑的积极影响.
研究的目的:
- 系统地审查L. johnsonii在消化系统疾病中的机制和临床应用.
- 通过微生物群-肠道-器官轴探索其系统调节作用.
- 评估其在预防和治疗胃肠道疾病方面的潜力.
主要方法:
- 整理和分析最近关于L. johnsonii. 的研究成果.
- 评估其调节肠道屏障功能,免疫反应和神经内分泌通路的机制.
- 使用实验性分离,鉴定和细菌群体的定量分析.
主要成果:
- 在炎症性肠病 (IBD),肠道感染和与H. pylori相关的胃炎方面,L. johnsonii显示出显著的干预潜力.
- 它在非酒精性脂肪肝疾病和神经退行性疾病中显示出前途.
- 这些结果验证了它在维持肠道平衡,调节新陈代谢和脑肠轴功能方面的作用.
结论:
- L. johnsonii是一种有前途的益生菌,可以促进消化系统健康,调节免疫力,肠道屏障和微生物群.
- 为了准确的治疗应用,需要对其机制进行进一步的研究.
- 它为未来的治疗提供了坚实的理论和实验基础.
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