早期婴儿白质管道的微观结构预测了随后情绪和情绪调节的变化
Yicheng Zhang1,2, Layla Banihashemi1,2, Amelia Versace2
1University of Pittsburgh Swanson School of Engineering, Department of Bioengineering, Pittsburgh, PA.
Genomic psychiatry : advancing science from genes to society
|August 18, 2025
概括
婴儿早期的白质微观结构预测了情绪和调节的变化. 小子和环带的特定模式与发展负面情绪,积极情绪和舒适性有关,为早期精神病理学提供了潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 生物标志物 生物标志物
背景情况:
- 婴儿期涉及到快速的情绪发展和情绪调节的变化.
- 了解这些变化的神经支对于识别早期精神病理学至关重要.
- 白质 (WM) 管道连接关键的情感相关的神经网络,影响情感发展.
研究的目的:
- 调查特定区域的WM微观结构如何预测婴儿情绪和调节的发育变化.
- 探索WM完整性和消极情绪 (NE),积极情绪 (PE) 和舒适性出现之间的关系.
- 识别情绪和行为障碍的潜在早期神经生物标志物.
主要方法:
- 使用神经元定向分散和密度成像 (NODDI) 和扩散张力成像 (DTI) 来评估WM微观结构.
- 分析了WM通道,包括小子 (FM),环膜束 (CB) 和未结合 (UF).
- 与护理人员报告的婴儿NE,PE和soothability相关的WM特征,控制社会人口统计因素.
主要成果:
- 在3个月大的婴儿中,FM的特定微观结构特征预测了NE的增加,而左边CB的特征预测了PE的增加和9个月的可溶性.
- 在FM中,较高的神经元分散和较低的纤维对齐与NE的较大增加有关.
- 较高的神经元密度/分散和左侧CB的较低对齐与PE和可吸收性更大的增加有关.
- 结果在独立样本中复制,证实了关联的稳定性.
结论:
- 早期婴儿的WM微观结构特征显著支持情绪和情绪调节的发展.
- 特定的WM通道特征可以作为情绪和行为发展的早期预测生物标志物.
- 这项研究提供了关于早期情绪发育和精神病理风险的神经基础的见解.
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