抗生素使用与抗生素耐药性之间的相关性:一项为期3年的回顾性研究
Ann Lisa Arulappen1,2, Amer Hayat Khan1, Syed Shahzad Hasan3
1Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, University Science Malaysia, Georgetown, Malaysia.
Frontiers in cellular and infection microbiology
|August 18, 2025
概括
耐多药微生物是一个日益严重的公共卫生问题. 这项研究发现,特定抗生素使用和耐药性率之间存在强烈的正相关性,这表明有针对性的控制可以减轻这种威胁.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 耐多药 (MDR) 微生物对全球健康构成重大威胁.
- 增加抗生素的使用与MDR细菌病原体的增加有关.
研究的目的:
- 为了确定抗生素使用和抗生素耐药性之间在三年时间内的相关性.
- 调查细菌耐药性模式的趋势及其与抗菌素处方的关联.
主要方法:
- 进行了一项回顾性横截面研究.
- 阳性细菌培养和总抗生素使用数据从城的六家医院收集了三年 (2021年1月至2023年12月) 的数据.
- 使用了方便的抽样.
主要成果:
- 在研究期间,在各种样本类型中观察到微生物分布和流行率的显著变化.
- 甲素耐药黄金葡萄球菌 (MRSA),Klebsiella pneumoniae和Pseudomonas aeruginosa在血液培养分离物中显示出显著的变化.
- 在第三代头素使用率和扩展谱β-乳糖酶 (ESBL) 率 (r=0.777,p=0.433) 之间发现了强烈的正相关性.
- 在碳烯使用率和碳烯耐药性肠道细菌 (CRE) 率 (r=0.762,p=0.448) 之间也观察到强烈的正相关性.
结论:
- 控制特定抗生素的使用至关重要,例如第三代类药物和碳类药物.
- 有针对性的抗生素管理可以帮助缓解MDR微生物的日益流行.
- 这些发现突显了抗菌素处方模式和耐药性的出现之间的直接联系.
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