在双相躁狂的缓解过程中,腹部前额外皮下皮层网络连接的变化
Jennifer E Siegel-Ramsay1, Elizabeth Lippard1, Thomas Blom2
1Department of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas, Austin, TX, USA.
Journal of mood and anxiety disorders
|August 18, 2025
概括
双极性障碍的缓解包括明显的前额叶下皮层网络变化,特别是在注意力任务期间. 虽然连接性有所改善,但尽管症状恢复,一些异常可能会持续存在.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 风前额叶下皮层网络失调与双相情感障碍有关.
- 了解情感情节缓解期间的连接性变化至关重要.
研究的目的:
- 在躁狂症缓解期间,研究双相I型精神障碍患者前额叶-皮下连接的纵向变化.
主要方法:
- 随访了35名双相I型精神障碍患者进行了为期8周的躁狂治疗.
- 使用混合模型,比较汇款与非汇款群体的连接性变化.
- 在基线和第1周和第8周使用了带有情绪分心因子 (CPT-END) 的连续执行任务.
主要成果:
- 观察到中部前额叶皮和右下额叶回环 (pars triangularis连接性) 中显著的分组时间相互作用.
- 在前额叶皮和左丘脑,双边杏仁体和前前带皮层之间也发现了按时间分组的相互作用.
结论:
- 截然不同的腹部前额外外皮下连接模式在注意力任务期间表现出双相情感障碍缓解的特征.
- 缓解与更规范的中部前额前-丘脑和中部前额前-腹侧前额皮质连接相关.
- 腹部前额前-侧/侧连接可能会改善,但不会完全正常化,这表明残留异常.
更多相关视频
08:23A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
Published on: November 13, 2016
11.3K
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.3K
相关概念视频
Bipolar Disorder
142
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
142
Mania and Antimanic Drugs: Overview
319
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
319
