经过手术治疗的患者的绝经后卵巢过高雄性病:一个病例报告和范围审查与个体患者的数据分析
Angelo Forte1, Lanfranco D'Elia1, Carmine De Luca1
1Department of Clinical Medicine and Surgery, Federico II University, Napoli, Italy.
Frontiers in endocrinology
|August 18, 2025
概括
绝经后女性的高雄性质症 (PH) 可能源于卵巢瘤或其他卵巢疾病. 特定的生化标志物可以帮助区分瘤和非瘤原因,帮助诊断和治疗.
科学领域:
- 内分泌学 在内分泌学.
- 妇科瘤学 妇科瘤学
- 生殖医学 生殖医学
背景情况:
- 绝经后的高雄性质症 (PH) 是一种罕见的疾病,在绝经后出现过多的雄激素.
- 卵巢疾病,无论是瘤还是非瘤,都是PH的已知的原因.
研究的目的:
- 描述由卵巢瘤引起的PH病例并进行手术治疗.
- 通过范围审查和个人患者数据 (IPD) 分析,通过手术治疗卵巢疾病的PH患者的生物化学和临床特征.
主要方法:
- 一个混合研究设计,将临床病例报告与IPD的范围审查相结合.
- 纳入标准:由于卵巢疾病的PH,手术治疗和组织学诊断.
主要成果:
- 一名患有莱迪格细胞瘤的患者经历了手术后PH的解决.
- 对280名卵巢PH (oPH) 患者的分析揭示了瘤 (n=174) 与非瘤 (n=106) oPH的不同概况.
- 瘤性oPH患者的BMI,LH,FSH较低,丸激素,DHEA-S,17-OH孕激素和雌激素水平较高.
- 确立了,LH,FSH和DHEA-S的生化值,以区分瘤和非瘤的oPH,灵敏度>68%和特异性>72%.
结论:
- 生物化学参数可以有效地支持在患有绝经后高雄性质症的患者卵巢瘤的诊断.
- 导致PH的卵巢疾病的手术治疗在研究队列中导致没有复发的解决.
相关概念视频
Hormonal Control of the Ovarian Cycle
2.7K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
2.7K
Oogenesis
64.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
64.4K
Menopause
248
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
248


