为最大限度地保持生物活性优化加工方法:对干 (Eriobotrya japonica) 花及其粉状提取物的比较代谢分析
Mingzheng Duan1, Jieming Feng1, Jing-Han Feng1
1Key Laboratory for Research on Zhaotong Apple Resources, College of Agronomy and Life Sciences, Zhaotong University, Zhaotong, China.
Frontiers in nutrition
|August 18, 2025
概括
冷干燥最好的保存loquat花的黄类药物用于营养品. 热干燥降解了一些化合物,但增强了其他化合物,为功能性食品和草药提供了独特的加工益处.
科学领域:
- 植物化学 植物化学
- 食品科学 食品科学 食品科学
- 营养保健品 营养保健品
背景情况:
- 洛卡特 (Eriobotrya japonica) 的花含有生物活性黄.
- 收获后加工显著影响着黄酸含量和营养价值.
- 了解干燥方法对于最大限度地提高花生物活性至关重要.
研究的目的:
- 评估热干燥 (HD) 和冷干燥 (FD) 对洛卡特花中的黄类固体保留的影响.
- 为了比较HD和FD处理的花提取物的抗氧化活性.
- 引导开发用于功能性食品和草药的标准化花产品.
主要方法:
- 用UPLC-MS/MS代谢学来进行详细的黄类蛋白质分析.
- 抗氧化剂测试用于量化提取物的生物活性.
- 多变量统计分析以评估样本聚类和代谢物稳定性.
主要成果:
- 与热干燥 (HD) 相比,冷干燥 (FD) 显著保留了可热化类黄,显示出更高水平的氨和氨3-O-β-D-sambubioside.
- 热干燥 (HD) 降解了一些黄类化合物,但增强了其他如6-基醇和甲基西.
- 冷干燥粉 (FDP) 显示出优异的抗氧化活性,与较高的埃里奥迪克提醇石灰水平相关.
结论:
- 冷干燥是保持广泛的生物活性黄胺的最佳方式,产生高质量的营养品.
- 热干燥提供了一种具有成本效益的方法,用于生产含有特定热稳定化合物的提取物.
- 处理方法的选择应平衡生物活性保存与生产效率,用于花的应用.
相关概念视频
Bioavailability: Influencing Factors
Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
Measurement of Bioavailability: Pharmacodynamic Methods
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...


