主要肝癌负担及其与西太平洋地区卫生发展的关联,1990-2021年
Teng-Chao Zhou1,2, Dan Qin3, Peng Yan1,2
1Vascular Disease Research Center of Hunan Provincial Geriatric Institute (SLYS04), Changsha, China.
Frontiers in oncology
|August 18, 2025
概括
尽管控制了病毒性肝炎,但西太平洋地区的肝癌负担正在上升. 需要综合战略来解决肝癌的病毒性,代谢性和与酒精有关的原因.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 肝癌 (LC) 在西太平洋地区 (WPR) 是一个重大的公共卫生挑战.
- 该地区因各种传染性和非传染性病因而面临越来越多的LC负担.
- 了解LC趋势和促成因素对于有效的区域卫生战略至关重要.
研究的目的:
- 评估从1990年到2021年在WPR中原发性肝癌 (LC) 的负担.
- 检查LC负担与卫生系统发展指标之间的关联.
- 确定导致该地区LC负担上升的关键病因.
主要方法:
- 来自2021年全球疾病负担研究 (GBD) 数据的二次分析.
- 评估31个WPR国家/地区的LC负担指标 (发病率,流行率,死亡率,DALYs).
- 按性别,年龄,位置和五个主要病因 (HBV,HCV,酒精,NASH,其他) 的分层.
- 与健康的人力资源 (HRH),全民健康覆盖 (UHC) 和社会人口统计指数 (SDI) 的相关性分析.
主要成果:
- 经过年龄标准化的LCDDALY比率从每10万人口中的281.78增加到334.74 (1990-2021).
- 总的LC发病率几乎翻了一番,在蒙古,澳大利亚和中国显著增加.
- 乙型肝炎病毒 (HBV) 仍然是主要原因,但酒精和非酒精性脂肪肝炎 (NASH) 的负担显著增加.
- 肺结核负担与HRH,UHC和SDI有积极的相关性,特别是与HCV和NASH相关的肺结核.
结论:
- 尽管在病毒性肝炎控制方面取得了进展,但在WPR中肝癌负担的增加仍在持续.
- 综合策略对于对抗病毒性,代谢性 (NASH) 和与酒精有关的肝癌至关重要.
- 解决LC多方面的原因对于改善区域公共卫生结果至关重要.
相关概念视频
Diseases of the Liver and Gallbladder
976
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
976
Cancer Prevention
6.3K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.3K
Cancer Survival Analysis
453
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
453
Tumor Progression
6.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
Prevalence and Incidence
802
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
802
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K


