在法国使用高剂量的普雷加巴林和 gabapentin:一个回顾性,基于人口的队列研究
Thomas Soeiro1,2, Marina Uras2, Émilie Jouanjus1,3,4
1UMR 1106, INS, Inserm, Aix-Marseille University, Marseille, France.
The Lancet regional health. Europe
|August 18, 2025
概括
这项研究检查了法国的新用户的普雷加巴林和 gabapentin,发现高剂量使用是常见的,特别是与普雷加巴林. 诸如先前的阿片类药物暴露和多个处方者等因素增加了风险.
科学领域:
- 药物监督 药物监督 药物监督
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 滥用和滥用 gabapentinoid (普雷加巴林, gabapentin) 在法国越来越令人担忧.
- 了解新的用户模式对于监测和干预至关重要.
研究的目的:
- 描述从2017年到2021年在法国的普雷加巴林和 gabapentin 的新用户.
- 为了估计高剂量 gabapentinoid 使用的发生率.
- 为了确定与高剂量 gabapentinoid 使用相关的因素.
主要方法:
- 使用法国国家健康数据系统进行了回顾性,基于人口的队列研究.
- 包括新用户 (≥18岁) 在12个月内≥3次发放,在前12个月内没有先前发放.
- 高剂量使用定义为每日平均剂量超过最大推剂量;使用Cox模型分析的因素.
主要成果:
- 包括898,887名新的普雷加巴林使用者和271,832名新的 gabapentin 使用者.
- 高剂量使用的发病率:26.0/1000人/年 (普雷加巴林) 和10.0/1000人/年 (加巴丁).
- 相关因素包括先前接触其他 gabapentinoids,阿片类药物,年龄较小,男性性别和多处方者.
结论:
- 高剂量 gabapentinoid 的使用是一个重大问题,特别是与pregabalin.
- 特定的患者特征和处方模式与风险增加有关.
- 处方者在高危人群中开始使用 gabapentinoids 时需要高度谨慎.
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