相关实验视频
Updated: Sep 11, 2025
07:44
Localization of the Locus Coeruleus in the Mouse Brain
Published on: March 7, 2019
18.1K
深度大脑刺激会改变部对社会压力的反应,从激活到抑制
Sonia Torres-Sanchez1,2,3, Andre L Curtis4, Rita J Valentino4
1Neuropsychopharmacology & Psychobiology Research Group, Department of Neuroscience, University of Cádiz, Cádiz, Spain.
Neurobiology of stress
|August 18, 2025
概括
在大鼠中,腹中介前额叶皮层 (vmPFC) 的深度大脑刺激 (DBS) 改变了局部 (LC) - 上腺素 (NE) 系统中的压力反应. 在压力期间,DBS抑制了LC神经元,可能会防止与压力有关的神经精神问题.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经生物学 神经生物学 神经生物学
背景情况:
- 亚阴带皮层 (SCC) 的深度大脑刺激 (DBS) 显示出治疗耐药性抑郁症的前景.
- 临床前研究将腹中前额叶皮层 (vmPFC) 刺激与抗抑郁药的作用和位 (LC) - - 诺亚上腺素 (NE) 系统的调节联系起来.
研究的目的:
- 调查vmPFC DBS对大鼠中LC神经元活动中社会压力诱导的变化的影响.
- 了解vmPFC DBS如何影响LC-NE系统对急性和重复的社会压力的反应.
主要方法:
- 醒着的雄性老鼠经历了五天的社会失败压力.
- 在控制和vmPFC DBS组中记录了自发和听觉唤起的LC单个单元活动.
- 在急性 (第1天) 和重复性 (第5天) 压力期间,LC神经元活动在组之间进行了比较.
主要成果:
- 与对照组不同的是,vmPFC DBS在急性和重复的社会压力期间强烈抑制了LC神经元.
- 虽然急性压力在两组中都减少了引起的LC放电,但DBS阻止了反应持续时间的减少.
- 重复的压力增加了控制器中的LC听觉唤起的活动,这种效应被DBS抵消了.
结论:
- DBS治疗将压力诱导的LC活动转向抑制调制.
- 这种调制可能会增强LC-NE系统对压力诱导激发的弹性.
- 研究结果表明,DBS在缓解与压力相关的神经精神疾病方面具有潜在的机制.
相关概念视频
01:20Psychological Responses to Stress
99
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
99
01:24Physiological Foundation of Stress
157
Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Role of the Sympathetic Nervous System
Adrenaline triggers the...
157