系统性炎症反应指数调解了中风和高血压之间的关联:从2001年到2016年的NHANES横截面研究
Mingzhu Tang1, Fangming Diao1, Yaxian Dong1
1Department of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Frontiers in neurology
|August 18, 2025
概括
系统免疫反应指数 (SIRI) 与中风风险有关. 高血压影响SIRI和中风,SIRI部分调解了这种关系,特别是在男性中,这表明它作为生物标志物的潜力.
科学领域:
- 心血管研究研究心血管研究
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 系统性炎症与高血压和中风发展有关.
- 系统性免疫反应指数 (SIRI),从中性粒细胞,单细胞和淋巴细胞计数中得出的,表明免疫调节失调.
- 对于SIRI在高血压-中风联系中的调解作用尚不清楚.
研究的目的:
- 调查SIRI,高血压和中风之间的关联.
- 探索SIRI在高血压和中风之间的关系中的调解作用.
- 检查这些关联中的基于性别的差异.
主要方法:
- 从NHANES (2001-2016) 对9699名美国成年人的分析.
- 使用了物流回归,ROC曲线分析,调解分析和受限制的立方线.
- 分析是按性别分层的.
主要成果:
- SIRI与中风有显著的相关性 (OR=1.10).
- 高血压独立地与中风 (OR=2.06) 和较高的SIRI (β=1.07) 相关.
- SIRI部分调解了高血压与中风的相关性 (1.65%),男性 (3.38%) 的效果比女性 (1.16%) 更明显. 在一般人群和男性中观察到SIRI和中风之间的U形关系.
结论:
- 高血压,SIRI和中风是相互关联的,SIRI作为一个部分调解者.
- 在高血压患者中,SIRI可以作为预防中风的生物标志物和治疗标.
- 在SIRI的调解作用中存在性别差异.
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