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在非人类灵长类动物模型中,母亲的免疫激活改变了婴儿的注意力处理

J A Hubbard¹, S Chen², A M Iosif²

¹California National Primate Research Center, University of California Davis, California, 95616, USA.

Brain, behavior, & immunity - health

|August 18, 2025

概括

孕的母体免疫激活 (MIA) 改变了婴儿的注意力,MIA暴露的雄性对社会和抽象刺激表现出不典型的反应. 这些早期的注意力障碍可能为儿童的神经发育障碍提供了洞察力.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
灵长类动物模型

背景情况:

怀孕期间母亲感染与神经发育障碍有关.
孕产妇免疫激活 (MIA) 模型显示了细胞因子如何影响后代的大脑和行为.
非人类灵长类动物 (NHP) 模型比动物模型提供了更大的人类翻译潜力.

研究的目的:

为了研究暴露于MIA的雄性 rhesus的早期注意力发展.
评估婴儿MIA暴露子对新兴刺激的模仿能力和反应.
探索NHP MIA模型的翻译潜力,以了解人类妊娠暴露.

主要方法:

利用母体免疫激活 (MIA) 的 rhesus 模型.
在1周大时评估模仿社会信号.
进行视觉配对比较任务,使用抽象刺激 (1个月) 和社会刺激 (3-4个月).

主要成果:

暴露于MIA的婴儿表现出不典型的社会信号模仿.
与对照组相比,暴露于MIA的婴儿对新的抽象和社会刺激的观察时间较长.
对新奇事物的非典型反应在更容易的歧视任务中更为明显.

结论:

在MIA后的男性NHP后代中,早期的注意力过程受到干扰.
注意力受损,以较长的新刺激处理时间为特征,可能是神经发育变化的早期指标.
该NHP MIA模型提供了宝贵的转化见解,了解孕期母亲感染对后代神经发育的影响.

关键词:

早期发展早期发展模仿模仿模仿模仿模仿在MIA模型中,MIA模型是:神经发育障碍神经发育障碍 rhesus macaque 是一个大猩猩.视觉配对比较视觉配对比较

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Development of Immunocompetence

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